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Testing protein leverage in lean humans: a randomised controlled experimental study. PLoS One. 2011;6(10):e25929. https://pubmed.ncbi.nlm.nih.gov/22022472/

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Gosby AK, Lau NS, Tam CS, et al. Raised FGF-21 and triglycerides accompany increased energy intake driven by protein leverage in lean, healthy individuals: a randomised trial. PLoS One. 2016;11(8):e0161003. https://pubmed.ncbi.nlm.nih.gov/27536869/

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Fontana L, Cummings NE, Arriola Apelo SI, et al. Decreased consumption of branched-chain amino acids improves metabolic health. Cell Rep. 2016;16(2):520–30. https://pubmed.ncbi.nlm.nih.gov/27346343/

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Kitada M, Ogura Y, Monno I, Koya D. The impact of dietary protein intake on longevity and metabolic health. EBioMedicine. 2019;43:632–40. https://pubmed.ncbi.nlm.nih.gov/30975545/

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Mladenovic D, Radosavljevic T, Hrncic D, Rasic-Markovic A, Stanojlovic O. The effects of dietary methionine restriction on the function and metabolic reprogramming in the liver and brain – implications for longevity. Rev Neurosci. 2019;30(6):581–93. https://pubmed.ncbi.nlm.nih.gov/30817309/

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Cole JT. Metabolism of BCAAs. In: Rajendram R, et al, eds. Branched Chain Amino Acids in Clinical Nutrition. Vol 1. Springer Science+Business Media; 2015:13–24. https://link.springer.com/chapter/10.1007/978-1-4939-1923-9_2

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Kitada M, Ogura Y, Monno I, Koya D. The impact of dietary protein intake on longevity and metabolic health. EBioMedicine. 2019;43:632–40. https://pubmed.ncbi.nlm.nih.gov/30975545/

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Ables GP, Johnson JE. Pleiotropic responses to methionine restriction. Exp Gerontol. 2017;94:83–8. https://pubmed.ncbi.nlm.nih.gov/28108330/

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McCarty MF. GCN2 and FGF21 are likely mediators of the protection from cancer, autoimmunity, obesity, and diabetes afforded by vegan diets. Med Hypotheses. 2014;83(3):365–71. https://pubmed.ncbi.nlm.nih.gov/25015767/

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McCarty MF. The moderate essential amino acid restriction entailed by low-protein vegan diets may promote vascular health by stimulating FGF21 secretion. Horm Mol Biol Clin Investig. 2016;30(1). https://pubmed.ncbi.nlm.nih.gov/26872317/

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Lonnie M, Johnstone AM. The public health rationale for promoting plant protein as an important part of a sustainable and healthy diet. Nutr Bull. 2020;45(3):281–93. https://onlinelibrary.wiley.com/doi/10.1111/nbu.12453

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McCarty MF. Practical prospects for boosting hepatic production of the “pro-longevity” hormone FGF21. Horm Mol Biol Clin Investig. 2015;30(2). https://pubmed.ncbi.nlm.nih.gov/26741352/

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Castaño-Martinez T, Schumacher F, Schumacher S, et al. Methionine restriction prevents onset of type 2 diabetes in NZO mice. FASEB J. 2019;33(6):7092–102. https://pubmed.ncbi.nlm.nih.gov/30841758/

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Castaño-Martinez T, Schumacher F, Schumacher S, et al. Methionine restriction prevents onset of type 2 diabetes in NZO mice. FASEB J. 2019;33(6):7092–102. https://pubmed.ncbi.nlm.nih.gov/30841758/

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Longo VD, Mattson MP. Fasting: molecular mechanisms and clinical applications. Cell Metab. 2014;19(2):181–92. https://pubmed.ncbi.nlm.nih.gov/24440038/

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Hill CM, Albarado DC, Coco LG, et al. FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice. Nat Commun. 2022;13(1):1897. https://pubmed.ncbi.nlm.nih.gov/35393401/

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Estévez M, Xiong Y. Intake of oxidized proteins and amino acids and causative oxidative stress and disease: recent scientific evidences and hypotheses. J Food Sci. 2019;84(3):387–96. https://pubmed.ncbi.nlm.nih.gov/30714623/

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Seyedsadjadi N, Berg J, Bilgin AA, Braidy N, Salonikas C, Grant R. High protein intake is associated with low plasma NAD+ levels in a healthy human cohort. PLoS One. 2018;13(8):e0201968. https://pubmed.ncbi.nlm.nih.gov/30114226/

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Solon-Biet SM, Mitchell SJ, de Cabo R, Raubenheimer D, Le Couteur DG, Simpson SJ. Macronutrients and caloric intake in health and longevity. J Endocrinol. 2015;226(1):R17–28. https://pubmed.ncbi.nlm.nih.gov/26021555/

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Brandhorst S, Longo VD. Protein quantity and source, fasting-mimicking diets, and longevity. Adv Nutr. 2019;10(Suppl_4):S340–50. https://pubmed.ncbi.nlm.nih.gov/31728501/

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Lee C, Longo VD. Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene. 2011;30(30):3305–16. https://pubmed.ncbi.nlm.nih.gov/21516129/

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Lee C, Safdie FM, Raffaghello L, et al. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res. 2010;70(4):1564–72. https://pubmed.ncbi.nlm.nih.gov/20145127/

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Lee C, Raffaghello L, Brandhorst S, et al. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med. 2012;4(124):124ra27. https://pubmed.ncbi.nlm.nih.gov/22323820/

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Thissen JP, Ketelslegers JM, Underwood LE. Nutritional regulation of the insulin-like growth factors. Endocr Rev. 1994;15(1):80–101. https://pubmed.ncbi.nlm.nih.gov/8156941/

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Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO. Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell. 2008;7(5):681–7. https://pubmed.ncbi.nlm.nih.gov/18843793/

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Allen NE, Appleby PN, Davey GK, Kaaks R, Rinaldi S, Key TJ. The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans. Cancer Epidemiol Biomarkers Prev. 2002;11(11):1441–8. https://pubmed.ncbi.nlm.nih.gov/12433724/

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Allen NE, Appleby PN, Davey GK, Key TJ. Hormones and diet: low insulin-like growth factor-I but normal bioavailable androgens in vegan men. Br J Cancer. 2000;83(1):95–7. https://pubmed.ncbi.nlm.nih.gov/10883675/

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Fontana L, Klein S, Holloszy JO. Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk. Am J Clin Nutr. 2006;84(6):1456–62. https://pubmed.ncbi.nlm.nih.gov/17158430/

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Dunn SE, Kari FW, French J, et al. Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res. 1997;57(21):4667–72. https://pubmed.ncbi.nlm.nih.gov/9354418/

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Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO. Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell. 2008;7(5):681–7. https://pubmed.ncbi.nlm.nih.gov/18843793/

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McCarty MF. A low-fat, whole-food vegan diet, as well as other strategies that down-regulate IGF-I activity, may slow the human aging process. Med Hypotheses. 2003;60(6):784–92. https://pubmed.ncbi.nlm.nih.gov/12699704/

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Murphy N, Carreras-Torres R, Song