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Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol. 2011;95(3):373–95. https://pubmed.ncbi.nlm.nih.gov/21930182/

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Zhao L, Cao J, Hu K, et al. Sirtuins and their biological relevance in aging and age-related diseases. Aging Dis. 2020;11(4):927–45. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390530/

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Grabowska W, Sikora E, Bielak-Zmijewska A. Sirtuins, a promising target in slowing down the ageing process. Biogerontology. 2017;18(4):447–76. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514220/

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Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 1999;13(19):2570–80. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC317077/

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Zhao L, Cao J, Hu K, et al. Sirtuins and their biological relevance in aging and age-related diseases. Aging Dis. 2020;11(4):927–45. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390530/

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Satoh A, Brace CS, Rensing N, et al. Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metab. 2013;18(3):416–30. https://pubmed.ncbi.nlm.nih.gov/24011076/

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Kanfi Y, Naiman S, Amir G, et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature. 2012;483(7388):218–21. https://pubmed.ncbi.nlm.nih.gov/22367546/

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Brenner C. Sirtuins are not conserved longevity genes. Life Metabolism. Published online September 22, 2022. https://academic.oup.com/lifemeta/advance-article/doi/10.1093/lifemeta/loac025/6711379. Accessed December 27, 2022.; https://academic.oup.com/lifemeta/article/1/2/122/6711379

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Giblin W, Skinner ME, Lombard DB. Sirtuins: guardians of mammalian healthspan. Trends Genet. 2014;30(7):271–86. https://pubmed.ncbi.nlm.nih.gov/24877878/

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Wang RH, Sengupta K, Li C, et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell. 2008;14(4):312–23. https://pubmed.ncbi.nlm.nih.gov/18835033/

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Lee SH, Lee JH, Lee HY, Min KJ. Sirtuin signaling in cellular senescence and aging. BMB Rep. 2019;52(1):24–34. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386230/

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Watroba M, Szukiewicz D. The role of sirtuins in aging and age-related diseases. Adv Med Sci. 2016;61(1):52–62. https://pubmed.ncbi.nlm.nih.gov/26521204/

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Palacios JA, Herranz D, De Bonis ML, Velasco S, Serrano M, Blasco MA. SIRT1 contributes to telomere maintenance and augments global homologous recombination. J Cell Biol. 2010;191(7):1299–313. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010065/

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Morris BJ. Seven sirtuins for seven deadly diseases of aging. Free Radic Biol Med. 2013;56:133–71. https://pubmed.ncbi.nlm.nih.gov/23104101/

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Giblin W, Skinner ME, Lombard DB. Sirtuins: guardians of mammalian healthspan. Trends Genet. 2014;30(7):271–86. https://pubmed.ncbi.nlm.nih.gov/24877878/

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Flachsbart F, Croucher PJP, Nikolaus S, et al. Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity. Exp Gerontol. 2006;41(1):98–102. https://pubmed.ncbi.nlm.nih.gov/16257164/

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Houtkooper RH, Pirinen E, Auwerx J. Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol. 2012;13(4):225–38. https://pubmed.ncbi.nlm.nih.gov/22395773/

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Cantó C, Gerhart-Hines Z, Feige JN, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 2009;458(7241):1056–60. https://pubmed.ncbi.nlm.nih.gov/19262508/

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Xu W, Deng YY, Yang L, et al. Metformin ameliorates the proinflammatory state in patients with carotid artery atherosclerosis through sirtuin 1 induction. Transl Res. 2015;166(5):451–8. https://pubmed.ncbi.nlm.nih.gov/26141671/

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Dang W. The controversial world of sirtuins. Drug Discov Today Technol. 2014;12:e9–17. https://pubmed.ncbi.nlm.nih.gov/25027380/

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Guerra B, Guadalupe-Grau A, Fuentes T, et al. SIRT1, AMP-activated protein kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise: influence of glucose ingestion. Eur J Appl Physiol. 2010;109(4):731–43. https://pubmed.ncbi.nlm.nih.gov/20217115/

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Guerra B, Guadalupe-Grau A, Fuentes T, et al. SIRT1, AMP-activated protein kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise: influence of glucose ingestion. Eur J Appl Physiol. 2010;109(4):731–43. https://pubmed.ncbi.nlm.nih.gov/20217115/

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Asghari S, Asghari-Jafarabadi M, Somi MH, Ghavami SM, Rafraf M. Comparison of calorie-restricted diet and resveratrol supplementation on anthropometric indices, metabolic parameters, and serum sirtuin-1 levels in patients with nonalcoholic fatty liver disease: a randomized controlled clinical trial. J Am Coll Nutr. 2018;37(3):223–33. https://pubmed.ncbi.nlm.nih.gov/29313746/

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Crujeiras AB, Parra D, Goyenechea E, Martínez JA. Sirtuin gene expression in human mononuclear cells is modulated by caloric restriction. Eur J Clin Invest. 2008;38(9):672–8. https://pubmed.ncbi.nlm.nih.gov/18837744/

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Draznin B, Wang C, Adochio R, Leitner JW, Cornier MA. Effect of dietary macronutrient composition on AMPK and SIRT1 expression and activity in human skeletal muscle. Horm Metab Res. 2012;44(9):650–5. https://pubmed.ncbi.nlm.nih.gov/22674476/

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Lilja S, Stoll C, Krammer U, et al. Five days periodic fasting elevates levels of longevity related Christensenella and sirtuin expression in humans. Int J Mol Sci. 2021;22(5):2331. https://pubmed.ncbi.nlm.nih.gov/33652686/

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Heilbronn LK, Civitarese AE, Bogacka I, Smith SR, Hulver M, Ravussin E. Glucose tolerance and skeletal muscle gene expression in response to alternate day fasting. Obes Res. 2005;13(3):574–81. https://pubmed.ncbi.nlm.nih.gov/15833943/

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Mansur AP, Roggerio A, Goes MFS, et al. Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: a randomized trial. Int J Cardiol. 2017;227:788–94. https://pubmed.ncbi.nlm.nih.gov/28029409/

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Civitarese AE, Carling S, Heilbronn LK, et al. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med. 2007;4(3):e76. https://pubmed.ncbi.nlm.nih.gov/17341128/

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Cantó C, Gerhart-Hines Z, Feige JN, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 2009;458(7241):1056–60. https://pubmed.ncbi.nlm.nih.gov/19262508/

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Giblin W, Skinner ME, Lombard DB. Sirtuins: guardians of mammalian healthspan. Trends Genet. 2014;30(7):271–86. https://pubmed.ncbi.nlm.nih.gov/24877878/

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Watroba M, Szukiewicz D. The role of sirtuins in aging and age-related diseases. Adv Med Sci. 2016;61(1):52–62. https://pubmed.ncbi.nlm.nih.gov/26521204/

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Giblin W, Skinner ME, Lombard DB. Sirtuins: guardians of mammalian healthspan. Trends Genet. 2014;30(7):271–86. https://pubmed.ncbi.nlm.nih.gov/24877878/

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